diff --git a/cve_bin_tool/version_signature.py b/cve_bin_tool/version_signature.py
index cd10875b64..e5b81bbb9b 100644
--- a/cve_bin_tool/version_signature.py
+++ b/cve_bin_tool/version_signature.py
@@ -40,7 +40,10 @@ def dbname(self) -> str:
 
     def open(self) -> None:
         """Opens connection to sqlite database."""
-        self.conn = sqlite3.connect(self.dbname)
+        # Ensure the cache directory exists before connecting
+        db_path = Path(self.dbname)
+        db_path.parent.mkdir(parents=True, exist_ok=True)
+        self.conn = sqlite3.connect(db_path)
         self.cursor = self.conn.cursor()
 
     def close(self) -> None: